Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. weakness and fatigue (tiredness) headaches. Here we look at how Zetia and Lipitor are alike and different. Zetia is also available in a generic form called ezetimibe. Like most drugs, Zetia can cause an allergic reaction in some people. Side effects may be more likely in older adults. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. dark colored urine. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. This can increase your risk of side effects from either medication. Zetia generally costs less than Lipitor. Talk with your doctor about birth control options that may be best for you. Before taking Zetia, talk with your doctor about your health history. Zetia is sometimes used with medications in the statin drug class. Below are examples of these side effects. Zetia is sometimes used with medications in the statin drug class. Some people with POTS also may have one or more . Statins are drugs used to lower cholesterol. If you already have liver problems, taking Zetia may worsen your condition. Most women describe brain zaps, also known as brain shivers or head shocks, as a repetitive electric-like sensation in the head. joint or muscle pain*. This is a serious medical condition that, if left untreated, can lead to kidney damage. This active drug is also available as a generic medication. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. For more information, see the How Zetia works section below. Zetia contains the active drug ezetimibe. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . The heartbeat increases with a feeling of the heart fluttering. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Cholestyramine (Prevalite) is a drug used to treat high cholesterol. (A class of drugs is a group of medications that work in a similar way.) Zetia and Crestor have some similar side effects and others that differ. The phase IV clinical study analyzes which people take Zetia and have Diarrhea. Fenofibrate belongs to the fibrate drug class. But it may be a sign that your liver isnt working as well as it should. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. shortness of breath or troubled breathing. However, it isnt known how Zetia may affect these risks. (Mixed hyperlipidemia is also known as mixed high cholesterol.). Youll also need to check your insurance plan, as it may only cover one or the other. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. Below are examples of these side effects. Plant sterols are similar to cholesterol. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. They often originate at the base of the skull and spreading on the back of the head and neck. Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. This can cause gallstones (hardened stones in your gallbladder). (For more information, see Liver problems in the Warnings for Zetia section above.). Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. Do not use more Zetia than your doctor recommends. If youre concerned about joint pain while using Zetia, talk with your doctor. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . Each type is described below in more detail. (A drug class is a group of medications that work in a similar way.) If youre pregnant or breastfeeding, or if youre planning to become pregnant or breastfeed, tell your doctor. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. The cause of the disorder is unknown. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. If your doctor recommends that you stop taking Zetia, they may suggest another treatment option for your condition. And taking it with Zetia and a statin likely wont cause any problems. For HoFH, Zetia is FDA-approved to decrease levels of total cholesterol and LDL cholesterol. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. Can diet help improve depression symptoms? Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. 1. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. MS: Can the Mediterranean diet help preserve cognitive health? Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. It can develop suddenly or gradually over time. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. Less commonly, taking Zetia may lead to serious side effects. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. * This is a partial list of mild side effects from Zetia. This may increase your risk of side effects. Is it harmful to take a coenzyme Q10 (CoQ10) supplement along with Zetia to help prevent muscle-related side effects? The effect of Zetia, atorvastatin, or simvastatin on other types of cholesterol levels in this study isnt known. High cholesterol occurs when you have more cholesterol in your blood than your body needs. This in turn increases clearance of cholesterol from the blood. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. For information on the effectiveness of Zetia, see the Zetia uses section below. Others may experience GI issues in conjunction with other symptoms, such as fainting. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. And generics tend to cost less than brand-name drugs. Zetia is available as a tablet that you take by mouth. * To learn more about this side effect, see the Side effects explained section below. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. A malfunctioning ANS is sometimes called 'dysautonomia'. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Talk with your doctor if you have questions about using Zetia to lower your triglyceride levels. unusual tiredness or weakness. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. The only FDA-approved dosage of Zetia for children is 10 mg once a day. * Sex and gender exist on spectrums. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Statins are commonly prescribed with Zetia to treat certain types of high cholesterol. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. What foods should I avoid while taking Zetia. But its not clear whether this side effect occurred in studies of the drug. It isnt known how long adults and children experienced diarrhea while taking Zetia in these clinical studies. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. Memory loss isnt a side effect of Zetia. An increase in levels of liver enzymes doesnt usually cause any symptoms. Use of the terms male and female in this article refers to sex assigned at birth. . Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. The generic is considered to be as safe and effective as the original drug. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. Dr. John Szawaluk answered. If you think youve taken too much of this drug, call your doctor. We avoid using tertiary references. Zetia contains the active drug ezetimibe. 2. Forget HDL and LDL. Uses. For most people, CoQ10 isnt a harmful or dangerous supplement. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Tell your doctor if youre experiencing bothersome side effects from Zetia. Talk with your doctor about the risks of taking Zetia with warfarin. People who may be at higher risk of this side effect include those who: Tell your doctor if any of the above apply to you before starting Zetia treatment. But keep in mind that Zetia is used to reduce cholesterol levels in your blood. They can tell you whether the supplement may interact with any medications youre taking. Heres some detail on certain side effects this drug may or may not cause. Statin drugs may pass into breast milk. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. It also helps keep the drug from harming the environment. This is because large meals can cause blood to pool excessively in the abdomen. Talk with your doctor right away if you have fever or chills with your joint pain. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). Youll likely take it once a day. Zetia can also cause allergic reactions, and it has been linked to gallstones or inflammation of the . However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. Diarrhea is a common side effect of Zetia. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. Currently GARD aims to provide the following information for this disease: Population Estimate: This section is currently in development. shaking and sweating. Zetia shouldnt cause weight gain or weight loss. Learn how we can help. (Primary hyperlipidemia is also called primary high cholesterol.) Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. It belongs to a class of drugs called cholesterol absorption inhibitors. There are no known interactions between Zetia and alcohol. However, you may still experience muscle problems if you use Zetia alone. Inability to speak. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. The heart beats faster to pump it up to the brain, but with little success. They may have a preference for one version or the other. The Food and Drug Administration (FDA) approves prescription drugs such as Zetia to treat certain conditions. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. You can take Zetia with or without food. Medications in this class prevent your small intestine from absorbing cholesterol. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). The insurance company will review the prior authorization request and decide if the drug will be covered. All rights reserved. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. Cholesterol itself isnt a harmful substance. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. In studies, weight changes didnt occur in people who took the drug. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. If you have any questions about eating certain foods while taking Zetia, talk with your doctor. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. You can also ask your pharmacist for information on how to dispose of your medication. Porphyrias have been associated with POTS symptoms (Stewart & Hensley, 1981). For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Brand-name medications usually cost more than generics. When this happens, more cholesterol can then be cleared from your blood by your liver. The following information describes dosages that are commonly used or recommended. Legal news and analysis on health care, hospitals, insurers, medical suppliers. Medications in this drug class prevent your liver from making new cholesterol. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. Zetia is primarily cleared from the body through fecal excretion. Most of Zetias side effects should go away within a few days or weeks. These drugs havent been directly compared in clinical studies. Zetia is sometimes used with medications in the statin drug class. The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. It belongs to a class of drugs called cholesterol absorption inhibitors. You may be able to find testimonials online from people who take Zetia. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. If youve noticed memory problems while taking Zetia, talk with your doctor. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Fenofibrate is a drug used to lower your triglyceride levels. But new medications can help lower cholesterol and improve heart health. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. 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